Department of Surgery, University of North Carolina, Chapel Hill, NC 27599-7081, USA.
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A 38-year-old male presented with painful obstructive jaundice. Ultrasound showed biliary dilatation and a duplicated gallbladder (DG). Magnetic resonance cholangiopancreatography (MRCP) imaging confirmed the diagnosis of DG and raised the suspicion of a stricture in the distal common bile duct. Endoscopic retrograde cholangiogram, sphincterotomy with small stone extraction, and biliary stent placement were accomplished, and the patient was transferred to our tertiary center. Given the report of a stricture, endoscopic retrograde cholangiopancreatography (ERCP) was repeated and showed no duct narrowing or persistent choledocholithiasis, but only one cystic duct and gallbladder filled. The patient subsequently underwent laparoscopic cholecystectomy using top-down technique with complete resection of both gallbladders. Postoperatively, the patient underwent another ERCP for elevated bilirubin due ampullary edema. Subsequently, his bilirubin normalized and he was discharged home on postoperative day 5. DG is a rare anatomical finding that may be associated with choledocholithiasis and cholecystitis. In this case, a combination of radiographic, endoscopic and laparoscopic procedures was utilized to resolve the patient’s clinical problem.
Gallbladder, duplication, cholecystectomy
Duplicated gallbladder (DG) is an uncommon anomaly of the biliary system that may complicate the diagnosis and surgical management of symptomatic cholelithiasis. Medical historians disagree about the first reported case of DG. Boyden attribute the first documentation to Blasius in 1675, whereas Desolneux et al. and Udelsman and Sugarbaker both credit a sacrificial victim of Emperor Augustus in 31 BC as the first reported case. There is consensus, however, over the uncommon incidence of this anomaly in the human population, which remains at 0.02 to 0.03 percent[2,5,6].
DG is thought to be the result of excessive budding of the hepatic diverticulum during the development of the biliary tree. DG and its anatomical variations were initially described in 1926 by Boyden. In 1977, Harlaftis et al. categorized duplicated gallbladder anatomy into the split primordium and accessory gallbladder groups [Figure 1]. In the type 1, or split primordium group, DGs share a common cystic duct, and are further distinguished as septated, bilobed, and Y-shaped. The type 2, or accessory gallbladder group, is classified based on the presence of more than one cystic duct joining the biliary tree with two or more distinct gallbladder primordial. In this group, the gallbladder closest to the liver is termed the accessory gallbladder. It may be positioned under or within the liver, within the gastrohepatic ligament, or within the gallbladder fossa.
Figure 1. Types of gallbladder duplications. Adapted with permission from Harlaftis et al., Copyright Elsevier (1977)
With respect to clinical presentation, DGs are not necessarily characterized by a specific set of symptoms[1,6,10]. Therefore, DG may be discovered preoperatively, during surgery, or during specimen processing. Computed tomography (CT) scan, magnetic resonance cholangiopancreatography (MRCP), endoscopic retrograde cholangiopancreatography (ERCP), and percutaneous transhepatic cholangiography may all result in preoperative diagnosis that assists the surgeon in planning and conducting the operation. Treatment of DG via laparoscopy has been described on multiple occasions. Removal of all gallbladders is vital in preventing persistent cholecystitis and future symptomatic gallstones[3,8].
A 38-year-old male presented to his local emergency department with right upper quadrant (RUQ) abdominal pain, accompanied by nausea and vomiting. A CT scan showed two gallbladders with separate cystic ducts entering distinctly into the common bile duct. There was no evidence of cholecystitis. The patient’s pain resolved spontaneously and he was discharged home. Another episode of RUQ pain with nausea developed three months later, with radiation of the pain to his back. He also had jaundice, light-colored stools, and nausea. The patient again visited his local emergency department, where his bilirubin was 9.1 mg/dL. Subsequently, a RUQ ultrasound and MRCP verified duplicated gallbladder and now showed cholecystitis of the medial gallbladder. The common bile duct was dilated to 7.9 mm in diameter. An ERCP with sphincterotomy was performed and two tiny stones were retrieved. A biliary stent for stricture at the distal common bile duct was placed. The patient was transferred to our tertiary center for further management.
At our institution, a second ERCP was performed to further assess the common bile duct for a possible malignancy. In this study, no stricture was seen and the biliary stent was removed. Subsequently, he was taken to the operating room for laparoscopic cholecystectomy.
The operation was started by taking down omental adhesions and dissecting the peritoneum overlying the medial and lateral aspects of the gallbladders [Video 1]. Due to the extent of the inflammation and aberrant anatomy, a top-down dissection was then used to mobilize both gallbladders and confirm structures. During this dissection, the medial gallbladder was inadvertently entered. This decompressed the inflamed gallbladder and facilitated the rest of the operation. The cystic duct and artery of the lateral gallbladder were identified, isolated, doubly clipped and divided. Similarly, the cystic artery of the medial gallbladder was controlled. The medial cystic duct was the only remaining structure entering the gallbladder. Given the size of duct, it was divided using a stapler.
Postoperatively, the patient’s bilirubin continued to rise. A third ERCP on postoperative day 1 suggested ampullary edema and intrabiliary clot without evidence of biliary injury. His bilirubin normalized gradually, and he was discharged home on postoperative day 5.
DG is not associated with specific symptoms or even with a predisposition for gallstone formation. As such, the condition may persist unnoticed or undiagnosed[6,9]. When symptoms do occur, gallbladder duplication may go unappreciated due to the rare nature of the anomaly or the insensitivity of diagnostic testing. Diagnosis of DG may be mistaken for more common problems such as folded gallbladder, pericholecystic fluid, gallbladder diverticulum, Phrygian cap, vascular band, or focal adenomyomatosis[9,13].
In the case reported herein, a preoperative CT scan and RUQ ultrasound suggested DG, which was confirmed with MRCP. It has been suggested that ERCP is the most accurate test in displaying the biliary tract anatomy of gallbladder duplications, however ERCP is not indicated for most patients with biliary colic due to its invasive nature. In the present case, even though ERCP was performed for evaluation of the biliary stricture, it did not identify the medial gallbladder with an obstructed cystic duct. Therefore, we advocate consideration of cross-sectional imaging by CT or MRCP if RUQ ultrasound raises the possibility of gallbladder duplication.
For a surgeon without preoperative suspicion, certain intraoperative presentations of DG may be more difficult to recognize than others. Awareness of the variations is helpful. Septations and partial duplications with one cystic duct, complete duplications within a common peritoneal coat, and intrahepatic duplications may go unnoticed if the surgeon is not aware of the abnormalities. When identified preoperatively or at operation, the literature suggest benefit to removal of all gallbladders at a single operation to prevent persistent or recurrent symptoms[3,8,15]. In addition, multiple pathologies may exist. Roeder et al. reported a case of a triplicated gallbladder, where one had cholelithiasis and cholecystitis, a second had papillary adenocarcinoma, and a third was intrahepatic without disease. For these reasons, we agree a surgeon should endeavor to remove all gallbladders.
According to a growing number of case reports, cholecystectomy in the setting of gallbladder duplication may be challenging but is possible by laparoscopic approach[17-19]. Maddox and Demers suggest identification of each infundibulum-cystic duct junction to permit safe laparoscopic removal. In this case, we also utilized a top-down technique via laparoscopy to verify the anatomy and safely remove both gallbladders. Laparoscopic visualization was helpful in recognizing the anatomy.
If gallbladder duplication is missed by preoperative and intraoperative assessments, persistent or future biliary symptoms are possible. In this setting, a high degree of suspicion for persistent duplicated gallbladder must be considered.
In conclusion, duplicated gallbladder is a rare anatomical finding that may be associated with cholelithiasis and cholecystitis. In this case, a combination of radiographic, endoscopic and laparoscopic procedures was utilized to resolve the patient’s persistent right upper quadrant pain and jaundice.
Literature review: Ghaderi I, Flanagan E, Bhansali S, Farrell TM
Creation of manuscript: Ghaderi I, Flanagan E, Bhansali S, Farrell TM
Video creation: Ghaderi IFinancial support and sponsorship
Dr. Ghaderi’s fellowship training was supported by the Foundation for Surgical Fellowships.Conflicts of interest
The video was presented at American College of Surgeon Clinical Congress, Washington DC, October 2013. The authors declare that there are no conflicts of interest.Patient consent
The report was done with patient consent.Ethics approval
No ethics approval was needed.Copyright
© The Author(s) 2018.
1. Singh B, Ramsaroop L, Allopi L, Moodley J, Satyapal KS. Duplicate gallbladder: an unusual case report. Surg Radiol Anat 2006;28:654-7.DOIPubMed
2. Boyden EA. The accessory gall-bladder–an embryological and comparative study of aberrant biliary vesicles occurring in man and the domestic mammals. Dev Dyn 1926;38:177-231.DOI
3. Desolneux G, Mucci S, Lebigot J, Arnaud JP, Hamy A. Duplication of the gallbladder. A case report. Gastroenterol Res Pract 2009;2009:483473.DOIPubMedPMC
4. Udelsman R, Sugarbaker PH. Congenital duplication of the gallbladder associated with an anomalous right hepatic artery. Am J Surg 1985;149:812-5.DOI
5. Hishinuma M, Isogai Y, Matsuura Y, Kodaira M, Oi S, Ichikawa N, Kosukegawa M, Kuriki K. Double gallbladder. J Gastroenterol Hepatol 2004;19:233-5.DOIPubMed
6. Buluş H, Koyuncu A, Coşkun A. Preoperative diagnosis of double gallbladder: a case report. Turk J Gastroenterol 2012;23:172-4.DOIPubMed
7. Harlaftis N, Gray SW, Skandalakis JE. Multiple gallbladders. Surg Gynecol Obstet 1977;145:928-34.PubMed
8. Horattas MC. Gallbladder duplication and laparoscopic management. J Laparoendosc Adv Surg Tech 1998;8:231-5.DOIPubMed
9. Maddox JM, Demers ML. Laparoscopic management of gallbladder duplication: a case report and review of literature. JSLS 1999;3:137-40.PubMedPMC
10. Causey MW, Miller S, Fernelius CA, Burgess JR, Brown TA, Newton C. Gallbladder duplication: evaluation, treatment, and classification. J Pediatr Surg 2010;45:443-6.DOIPubMed
11. Ozgen A, Akata D, Arat A, Demirkazik FB, Ozmen MN, Akhan O. Gallbladder duplication: imaging findings and differential considerations. Abdom Imaging 1999;24:285-8.DOIPubMed
12. Nursal TZ, Ulusan S, Tercan F, Yildirim S, Tarim A, Noyan T, Bilgin N. Laparoscopic management of gallbladder duplication. Int Surg 2007;92:195-7.PubMed
13. Goiney RC, Schoenecker SA, Cyr DR, Shuman WP, Peters MJ, Cooperberg PL. Sonography of gallbladder duplication and differential considerations. AJR Am J Roentgenol 1985;145:241-3.DOIPubMed
14. Heinerman M, Lexer G, Sungler P, Mayer F, Boeckl O. Endoscopic retrograde cholangiographic demonstration of a double gallbladder following laparoscopic cholecystectomy. Surg Endosc 1995;9:61-2.DOIPubMed
15. Silvis R, van Wieringen AJ, van der Werken CH. Reoperation for a symptomatic double gallbladder. Surg Endosc 1996;10:336-7.DOIPubMed
16. Roeder WJ, Mersheimer WL, Kazarian KK. Triplication of the gallbladder with cholecystitis, cholelithiasis, and papillary adenocarcinoma. Am J Surg 1971;121:746-8.DOI
17. Al Rawahi A, Al Azri Y, Al Jabri S, Alfadli A, Al Aghbari S. Successful laparoscopic management of duplicate gallbladder: a case report and review of literature. Int J Surg Case Rep 2016;21:142-6.DOIPubMedPMC
18. Cozacov Y, Subhas G, Jacobs M, Parikh J. Total laparoscopic removal of accessory gallbladder: a case report and review of literature. World J Gastrointest Surg 2015;7:398-402.DOIPubMedPMC
19. Shiba H, Misawa T, Ito R, Ohki K, Igarashi T, Yanaga K. Duplicated gallbladder. Int Surg 2014;99:77-8.DOIPubMedPMC
Masashi Isetani et al., Hepatoma Research, 2017