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Mini-invasive Surg 2018;2:27.10.20517/2574-1225.2018.28© The Author(s) 2018.
Open AccessOriginal Article

Clinical feasibility of sphincter-preserving resection with transanal rectal dissection for low-lying rectal cancer in Japanese patients: a single-center cohort study

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1Department of General and Gastroenterological Surgery, Toho University Omori Medical Center, Tokyo 143-8541, Japan.

2Department of Surgery, Jyujyo Hospital, Chiba 292-0003, Japan.

Correspondence Address: Dr. Kimihiko Funahashi, Department of General and Gastroenterological Surgery, Toho University Omori Medical Center, 6-11-1 Omorinishi, Ota-ku, Tokyo 143-8541, Japan. E-mail: kingkong@med.toho-u.ac.jp

    Science Editor: Gordon N. Buchanan | Copy Editor: Jun-Yao Li | Production Editor: Huan-Liang Wu
    ...

    © The Author(s) 2018. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

    Abstract

    Aim: Recently, the transanal down-to-up rectal dissection, a new approach to improve the difficult total mesorectal excision (TME) for low-lying rectal cancer, has been popularized. This study assessed the long-term oncologic and functional outcomes after sphincter-preserving resection combined with transanal rectal dissection (TARD) under direct vision for both complete TME and preservation of the internal anal sphincter (IAS) as much as possible to clarify the clinical feasibility of this approach.

    Methods: A prospective cohort study was conducted in 90 Japanese patients between April 2003 and March 2012.

    Results: Abdominoperineal resection (APR) was needed in 17 patients (18.9%) including 14 salvage APRs. Local recurrences occurred in 5 sphincter-preserving resection patients (6.8%). No significant between-group differences were observed in overall survival or 5-year disease-free survival. A significant benefit of preserving the internal anal sphincter completely in sphincter-preserving resection was found on the Wexner incontinence score (P = 0.005), low anterior resection syndrome score (P = 0.002), and visual analogue scale (P = 0.047).

    Conclusion: TARD, performed under direct vision for both complete TME and preservation of the IAS as much as possible in sphincter-preserving resections for low-lying rectal cancers in Japanese patients, does not negatively impact oncologic outcomes and could have the benefit of minimizing postoperative anorectal dysfunction by preserving the internal anal sphincter.

    Introduction

    In surgery for rectal cancer, total mesorectal excision (TME)[1,2] and negative circumferential resection margins[3,4] are prerequisites for minimizing local tumor recurrence after surgery for rectal cancer. However, male sex, high body mass index, visceral obesity, a narrow pelvis, bulky tumor and an advanced T-stage pose technical challenges during surgery due to poor visualization of the mesorectal planes, especially with laparoscopic surgery[5,6]. Actually, the ALaCart[7] and ACOSOG Z6051[8] randomized controlled trials failed to show the noninferiority of laparoscopic surgery compared with open surgery for oncologic outcomes. Additionally, minimizing postoperative anorectal dysfunction has been a major matter in sphincter preservation for low-lying rectal cancer (LRC) near the anus. Intersphincteric resection (ISR) makes sphincter preservation possible for many patients with LRC[9]. Laparoscopic ISR has been shown to be more feasible and beneficial than open ISR[10]. Recently, a new approach, the transanal total mesorectal excision (TaTME), has attracted increasing attention as a promising technique for rectal cancer patients who may be poor candidates for total TME. A transanal approach has another benefit: the level of the distal resection margin is determined as the first step in the anal canal, taking care to preserve the internal anal sphincter (IAS) as much as possible for LRC near the anus.

    More recently, TaTME has been shown to be feasible in a randomized trial in France[11], a case-matched study[12] and a meta-analysis[13]. However, its feasibility for those of Asian race, including Japanese patients, remains unclear. As the average body mass index in Japan increases each year[14,15], the transanal approach may represent a solution for obese Japanese patients with a narrow pelvis and a bulky mesorectum.

    The aim of this study was to clarify the clinical feasibility of this new technique by analyzing the long-term oncologic and functional outcomes after sphincter-preserving resection (spr) combined with transanal rectal dissection (TARD) under direct vision for both complete TME and preservation of the IAS as much as possible[16].

    Methods

    Patients

    The study was approved by the ethics committee of Toho University Omori Medical Center (No. 17-41). Informed consent was obtained from all patients in this study. All patients who underwent laparoscopic and open SPR combined with TARD for LRC from April 2003 to March 2012 were included in this prospective observational cohort study. We evaluated 90 patients undergoing laparoscopic and open SPR at our institution for the feasibility of TARD for LRC. The inclusion criterion was LRC located ≤ 5 cm from the anal verge. Patients of both sexes and various ages were included. The exclusion criteria for TARD included lesions classified as T4b or N2-3, lateral lymph-node involvement, and the presence of distant metastases. An immediate conversion to an abdominoperineal resection (APR) was performed if we observed any tumor invasion into the external anal sphincter or the levator ani muscle during the dissection of the internal anal sphincter and external anal sphincter muscles.

    Surgical technique

    The surgical technique for transanal retrograde dissection of the low rectum has been described previously[13][Figure 1]. Briefly, the anal canal was exposed using a self-retaining retractor (Lone Star Retractor; Lone Star Medical Products Inc., Houston, TX). The distal aspect of the canal at the lower margin of the tumor was closed using purse-string sutures under direct visualization, and the anal canal was irrigated with 5% povidone-iodine solution. Division of the rectum on the posterior side was then performed, taking care to preserve the IAS as much as possible. The rectum was circularly incised, closing the cut end with an interrupted suture, and the rectum (including the tumor) was mobilized proximally, exposing the levator ani muscle. If the surgeon suspected tumor invasion into the dissected plane, the procedure was immediately converted to an APR. The rectum, including the mesorectum, was divided and mobilized up to the peritoneal reflection on the anterior side and to the rectosacral ligament on the posterior side. The 10 o’clock and 2 o’clock positions around the prostate were dissected on the abdominal part of the organ in order to avoid excessive dissection around these positions that could cause nerve injury and result in sexual dysfunction[17].

    Figure 1. Photographs showing the procedure of an intersphincteric resection combined with transanal rectal dissection. A: Tumor was found at 4 cm from the anal verge, on the posterior side of the rectum; B-D: division of the rectum on the posterior side was performed, taking care to preserve the internal anal sphincter as much as possible. The rectum was circularly incised, closing the cut end with an interrupted suture, and the rectum (including the tumor) was mobilized proximally, exposing the levator ani muscle; E: the rectum, including the mesorectum, was divided and mobilized up to the peritoneal reflection on the anterior side and to the rectosacral ligament on the posterior side; F: a Lap Disc Mini (Hakko Co., Ltd, Chikuma-shi, Japan) was adapted to the anal canal to maintain pressure during laparoscopy; G-H: the rectum, including the entire mesorectum, was completely removed from the pelvic floor. To avoid nerve injury in this patient, Denonvilliers’ fascia was not dissected; I: the colon and rectum were extruded through the umbilical wound and resected; J: a coloanal anastomosis was hand-sutured transanally

    In the abdominal portion of a laparoscopic SPR, a Lap Disc Mini (Hakko Co., Ltd, Chikuma-shi, Japan) was adapted to the anal canal to maintain pressure during laparoscopy. A camera port was inserted into the umbilicus via a trocar; moreover, an operative port was inserted into the mid-lower abdominal region, and 2 additional operative ports were inserted into the left and right McBurney’s points. During routine intra-abdominal exploration, gauze was placed on the dissected plane as a landmark that could be identified, through the peritoneum, from the anterior side of the rectum. The sigmoid and descending colon were completely mobilized from the subretroperitoneal fascia to ensure that the subsequent coloanal anastomosis was free of tension. The sigmoid colon and its mesentery were then removed, and the lymph nodes around the inferior mesenteric artery were dissected using a harmonic scalpel; additionally, the inferior mesenteric artery was ligated at a high level using an endoclip. Denonvillier’s fascia was dissected, exposing, on the anterior side, the seminal vesicles and prostate gland in male patients and the posterior wall of the vagina in female patients. The lower rectum and mesorectum were mobilized from the sacrum, through the anus, on the divided plane between the visceral and parietal endopelvic fascia. The lateral ligaments of the rectum and the neurovascular bundle were gradually divided, using a harmonic scalpel, from the inner limit of the inferior hypogastric nerve fibers. The rectum, including the entire mesorectum, was completely removed from the pelvic floor. The colon and rectum were extruded through the umbilical wound and resected. A coloanal anastomosis was sutured transanally. Reconstruction was performed with a J-pouch or coloplasty, if possible. Finally, a diverting ileostomy was created; this was reversed 6 months after surgery. Although most parts of the procedure during the abdominal portion were performed by the surgical staff of the division of colorectal surgery, the anal portion of the surgery was performed only by the senior author (KF).

    Definition of ISR

    The ISR procedure partially or totally resects the IAS by dissecting the intersphincteric space. In this study, we defined partial ISR as a one-third resection of the upper part of the IAS between the dentate line and the intersphincteric groove, and we defined a massive ISR as a more than two-thirds resection between the dentate line and the intersphincteric groove. We take care to preserve the IAS as much as possible during division of the rectum. Rectal dissection beyond the dentate line with coloanal anastomosis was defined as a conventional coloanal anastomosis (conventional CAA).

    Functional assessment

    Anorectal function following ISR or conventional CAA was measured using structured questionnaires at regular intervals following closure of the diverting stoma. Patients answered questions on daily stool frequency and the presence of fecal urgency (incapacity to restrain defecation for more than 5 min). We also used the Wexner incontinence (WI) score[16], the low anterior resection syndrome (LARS) score[18], and a survey assessing the patients’ satisfaction with their daily bowel-movement habits that employed a visual analogue scale (VAS). Complete incontinence was defined as a WI score of 20. In this study, the ISR patients were divided into 2 groups: partial ISR and massive ISR.

    Postoperative follow-up

    After surgery, patients were followed in the clinic every 3 months to be monitored for cancer recurrence and anorectal function. Blood tests at each visit included carcinoembryonic antigen and carbohydrate antigen 19-9 (CA19-9) levels. Patients were evaluated every 3 months using computed tomography or abdominal ultrasonography for the first 3 years and every 6 months thereafter. Local recurrence was defined as any recurrence that was diagnosed or suspected in the pelvis, either alone or with other metastases.

    Function was assessed using a questionnaire that included questions on stool frequency and fecal urgency. We used the WI score and assessed patient satisfaction using the VAS score previously described. This questionnaire was administered by the medical staff to all patients who underwent SPR at all clinical follow-up appointments. We evaluated the effects of the degree of IAS resection on the patients’ long-term anorectal function.

    Statistical analysis

    Data were analyzed using either the chi-squared test or Fisher’s exact test. Continuous variables were compared using the Kruskal Wallis H-test. Survival rates were assessed using Kaplan-Meier curves and the log-rank test. A P value of < 0.05 was considered statistically significant. Statistical analyses were performed using Predictive Analytics SoftWare (PASW), version 18 (SPSS, Inc., Chicago, IL).

    Results

    Patient characteristics

    Ninety patients (63 male, 27 female) with a median age of 62 years (range 33-80 years) were enrolled. The median BMI was 22.5 kg/m2 (range 16.7-32.9 kg/m2). Fifteen patients (16.7%) had received preoperative chemoradiation therapy (pre-CRT). In this series, all tumors were designated as type II-III, according to Rullier’s classification[19]. Seventeen patients (18.9%) required intraoperative conversion to APR: in 14 patients, this was because of the surgeon’s suspicion for direct tumor invasion into the levator ani muscle, prostate, or vagina; in 2 patients, there was ischemia of the descending colon; and in 1 patient, anatomic disorientation occurred. In the 73 patients who underwent successful SPR, efforts were made to preserve the IAS as much as possible to avoid postoperative anorectal dysfunction. In 21 of these 73 patients (28.8%), the IAS was completely preserved, and the coloanal anastomosis was hand sewn; 33 patients underwent partial ISR, and 19 underwent massive ISR. According to Quirke’s classification, the weighted mean of the quality of the mesorectum dissection was complete TME in 94.5% and nearly complete TME in 1.4%. Also, the rate of involvement of the circumferential resection margin was 2.7%.

    The pathologic tumor-node-metastasis (pTNM) staging in the patients who underwent SPR was stage I in 27 patients (37.0%), stage II in 23 patients (31.5%), and stage III in 22 patients (30.1%). The pTNM staging of the patients who underwent APR was stage I in 3 patients (17.6%), stage II in 9 patients (52.9%), and stage III in 4 patients (23.5%). Because of a complete response to pre-CRT, pTNM staging could not be performed in 2 patients (1 in each group). Although in stage II and III advanced disease was observed more frequently in the patients who underwent APR, there was no statistically significant difference between the APR and SPR groups [Table 1].

    Table 1

    Patient characteristics of the APR and SPR groups

    SPR (n = 73)APR (n = 17)P value
    Gender (%)0.256
     Male49 (67.1)14 (82.4)
     Female24 (32.9)3 (17.6)
    Age, years (range)61 (33-79)69 (40-80)0.013
    BMI, kg/m2 (range)23.3 (16.7-32.9)21.6 (17.5-32.8)0.160
    Pre-CRT (%)14 (19.2)1 (5.9)0.286
    Operation type0.040
     Open 33 (45.2)13 (76.5)
     Laparoscopic40 (54.8)4 (23.5)
    Quality of TME (%)1.000
     Complete 69 (94.5)17 (100)
     Near complete1 (1.4)0
     NE30
    Circumferential resection margin (%)1.000
     Negative 68 (93.1)17 (100)
     Positive 2 (2.7)0
     NE30
    Maximum tumor size in specimen, mm (range)34.5 (8-109)
    Pathological TNM staging0.243
     I27 (37.0)3 (17.6)
     II23 (31.5)9 (52.9)
     III22 (30.1)4 (23.5)
     NE1 (1.4)1 (6.0)

    Oncologic results

    During a median follow-up period of 3958 days (range 2778-6583 days), recurrence developed in 13 of the SPR patients (17.8%) and in 5 of the APR patients (29.1%). Distant recurrence developed more frequently in the APR patients, while local recurrence occurred exclusively in those patients who underwent SPR [Table 2]. Local recurrences developed around the internal iliac artery in 4 patients and around the prostate in 1 patient. One patient with a local recurrence underwent pre-CRT because of locally advanced cancer (cT4N2M0), and the remaining 4 patients were diagnosed with clinical stage III disease [Table 3].

    Table 2

    Recurrence after surgery

    SPR (n = 73)APR (n = 17)P value
    Recurrence (%)13 (17.8)5 (29.1)0.317
     Local 5 (6.8)00.248
     Distant8 (11.0)5 (29.1)
      Liver 22
      Lung 51
      Other 12
    Median follow-up period, days (range)3958 (2778-6583)
    Table 3

    Details of local recurrence after surgery

    No.GenderAge (years)cTNMPre-CRTSurgical approachTumor size (mm)pTNMCRMLymphatic vessel invasionRecurrence siteTreatmentStatus
    1Male46T4N2M0P (grade 2)Open70T3N0M0CompleteNoneLt-lateral lymph nodeChemoAlive
    2Male 51T3N1M0NOpen85T4bN2bM0
    (prostate)
    IncompleteModerateLt-lateral lymph nodeRT + ChemoDead
    3Male63T3N1M0NOpen60T3N1bN0CompleteModerateRt-lateral lymph nodeRT + ChemoDead
    4Male63T3N1M0NOpen75T3N1bN0CompleteSlightPelvisChemoDead
    5Male59T3N1M0NLaparoscopic20T3N2aM0CompleteSlightProstateRT + Chemo TPEAlive

    The 5-year overall survival rates were 88.1% and 87.5% in the SPR and APR groups, respectively. The 5-year disease-free survival rates were 85.0% and 80.8% in the SPR and APR groups, respectively. No significant differences in either were observed between the 2 groups (P = 0.751 and P = 0.892, respectively). The 5-year overall survival rate in the patients who underwent SPR was 100% for those with stage I disease, 86.5% for stage II disease, and 72.1% for stage III disease [Figure 2].

    Figure 2. Kaplan-Meier survival rate in the sphincter-preserving resection and abdominoperineal resection groups. A: overall survival rate; B: disease-free survival rate; C: overall survival rate according to pathological stage in the sphincter-preserving resection group

    Functional results

    During a median follow-up period of 1450 days (range 475-2544 days), 11 patients did not respond to the questionnaire. Surveys were stopped in 4 patients because of cancer recurrence. Two patients did not consent to an ileostomal closure. One patient required a permanent colostomy because of a perineal hernia after a pelvic-bone fracture. Ultimately, anal function was assessed in 55 of the 73 SPR patients (75.3%): 18 conventional CAA patients, 22 partial ISR patients, and 15 massive ISR patients [Table 4]. The functional outcomes of the 3 groups are shown in Table 5.

    Table 4

    Characteristics of the CAA, partial ISR and massive ISR patients

    Conventional CAA
    (n = 18)
    Partial ISR (n = 22)Massive ISR (n = 15)
    Gender
     Male13177
     Female558
    Age, years (range)59 (46-79)62 (34-77)56 (33-70)
    BMI, kg/m2 (range)22.1(16.5-32.9)24.7 (16.9-31.2)20.4 (18.3-26.5)
    Pre-CRT (%)3 (16.7)5 (22.7)1 (6.7)
    Reconstruction
     Pouch 033
     Straight181912
    Complication related to anastomosis (%)04 (18.2)2 (13.3)
     Prolapse011
     Anastomotic structure031
    Table 5

    Long-term function after sphincter-preserving resection

    Conventional CAA
    (n = 18)
    Partial ISR (n = 22)Massive ISR (n = 15)P value
    Follow-up period, days (range)1096 (475-2508)1467 (748-2537)1814 (728-2544)-
    Daily bowel movements0.82.62.2NS
    Urgency (%)1 (5.6)6 (27.3)4 (26.7)NS
    Fecal incontinence02 (9.1)1 (6.7)NS
    WI score5 (0-14)10 (0-20)10 (5-20)0.005
    LARS score28 ± 633 ± 936 ± 3 0.002
    VAS score7.8 ± 1.56.4 ± 2.96.6 ± 1.50.047
    Complication related to coloanal anastomosis (%)04 (18.2)2 (13.3)NS
     Prolapse011
     Anastomotic stricture031

    A significant difference in the WI score (P = 0.005), LARS score (P = 0.002), and VAS score (P = 0.047) was observed between the 3 groups.

    Discussion

    Transanal approaches to pelvic dissection have attracted attention to improve oncologic and functional outcomes by providing better visualization and more accurate TME dissection. In 1984, Dr. Gerald Marks was the first surgeon to use a perineal approach to transanal dissection of the rectum for TME; his goal was to avoid leaving the patient with a permanent colostomy[20,21]. In April 2003, we implemented the TARD technique in laparoscopic SPR for LRC located ≤ 5 cm from the anal verge in order to achieve more accurate TME and to maintain the function of the IAS as much as possible after ISR[22]. A randomized trial showed that a transanal approach to TME was more effective than the conventional laparoscopic approach to TME in terms of negative circumferential resection margins and suggested that the perineal approach could be the new standard for laparoscopic SPR in Western patients with LRC[23]. However, in its long-term results, lower positivity of the circumferential resection margin did not translate into a decreased incidence of local recurrence[11]. Marks et al.[12] reported that the primary perineal approach reduces operative time and is associated with similar short- and long-term outcomes compared with the primary abdominal approach to laparoscopic ISR. On the other hand, two randomized controlled trials, the ALaCart[7] and ACOSOG Z6051[8] trials, failed to show the noninferiority of laparoscopic surgery compared with open surgery for oncologic outcomes. Two multi-center, randomized, controlled trials, COLORIII[24] and GRECCAR 11[25], will provide more definitive results.

    The feasibility and benefit of this approach for Asian patients, including Japanese patients, should be evaluated. To our knowledge, although there are many reports of SPR including ISR in Japanese patients[26-35], ours is the first to describe the long-term oncologic and functional outcomes of SPR via the transanal approach in the Japanese population.

    In the reports by Rouanet et al.[36], Denost et al.[23], Lacy et al.[37], Burke et al.[38], and Veltcamp Helbach et al.[39], CRM positivity was 2.5%, 4%, 6.4%, 4%, and 2.5%, respectively. In this series, 17 patients (18.9%) required conversion to APR. In 14 of these, salvage APR was performed because tumor invasion into the levator ani muscle, prostate, or vagina was suspected during rectal dissection. As final histopathology revealed a negative CRM for each of these patients, TARD could be a useful approach for clinical T4b tumors. A good CRM of 93.1% was shown in the SPR group as well. Patients who underwent SPR had an overall survival rate of 88.1% and a disease-free survival rate of 84.9% after 5 years. This was not significantly different from patients who underwent APR. These results show that TARD has a potential benefit of being able to allow immediate conversion to APR as a salvage procedure when tumor invasion to the rectal dissection plane is suspected during SPR for advanced disease categorized as type II-III according to Rullier’s classification. Local recurrence occurred in 6.8% of the SPR patients during a median follow-up period of 3958 days (range 2778-6583 days); these findings are similar to those of Rullier et al.[19] who reported rates from 5% to 9% in 135 conventional CAA patients, 131 partial-ISR patients, and 55 total-ISR patients. For unclear reasons, local recurrence was only observed after ISR in this series. All patients with local recurrence were male with stage III disease, and 1 had received pre-CRT. Histologically, locally advanced disease was observed in most patients. No technical errors were reported in the operative records.

    Postoperative anorectal function is a significant concern for patients undergoing SPR, including ISR. Although ISR has broadened the sphincter-preserving options for selected patients with LRC, impaired anorectal function after ISR remains a major problem. Many studies have found that patients undergoing SPR, including low anterior resection, conventional CAA, and ISR, are at risk for developing LARS (e.g., frequent bowel movements, urgency, and incontinence of flatus). A recent review found that, regardless of the use of preoperative irradiation, 0% to 5.9% of patients who undergo ISR require a colostomy for postprocedural anorectal dysfunction[40]. It is well known that the IAS plays an important role in fecal continence, and that extensive resection of the IAS during SPR is likely to impair anorectal function. Some risk factors associated with anorectal dysfunction after ISR include pre-CRT[41,42], total resection of the IAS[43-45], tumor level, height of the anastomosis[46], and patient age[30]. In this series, pre-CRT was administered to 14 patients with locally advanced disease. Pre-CRT has been shown to negatively affect postsurgical function[47,48].

    Most researchers agree that anorectal dysfunction after ISR improves as time proceeds, but any remaining postoperative anorectal dysfunction after IAS resection is significant.

    In this series, we were able to preserve the IAS completely in 18 patients (28.8%) using the TARD technique; consequently, this might minimize postoperative anorectal dysfunction in these patients. These results show again the significance of preserving the IAS for anorectal function after surgery[49].

    This study showed the clinical feasibility of TARD under direct vision in SPR for LRC. TARD could represent a step toward a minimally invasive, natural orifice, transluminal endoscopic surgery. However, this study is limited by its single-institution nature, its lack of a control group, and its small sample size. In addition, most TARD procedures were performed by a single surgeon (KF); therefore, the potential for selection bias is significant. Our data must be interpreted in the context of these potential biases. Recently, TaTME utilizing laparoscopic instruments has been developed as a novel alternative to intersphincteric resection that provides solutions to many of the limitations of TARD, as it is performed under direct visualization[50]. We recommend that further studies should be performed to confirm that transanal surgery is feasible and of benefit for Japanese and all Asian patients.

    Using TARD under direct vision during laparoscopic and open SPR for LRC has no negative effects on oncologic outcomes. However, resection of the IAS should be avoided, where possible, to minimize anorectal dysfunction after ISR. This approach is feasible for Japanese patients with LRC. Further studies that compare TaTME utilizing laparoscopic instruments with conventional transabdominal TME are required to fully understand the risks and benefits of this approach for the Japanese and greater Asian populations.

    Declarations

    Authors’ contributions

    Conception and design of the study: Teramoto T

    Collection and assembly of data: Shiokawa H, Ushigome M, Kaneko T, Kagami S, Koda T

    Analysis and interpretation of data: Koike J

    Availability of data and materials

    The data is presented and kept by the author and is available for scrutiny.

    Financial support and sponsorship

    None.

    Conflicts of interest

    The authors declare that there are no conflicts of interest.

    Ethical approval and consent to participate

    The Ethics Committee of Toho University Omori Medical Center (No. 17-41) approved the study, which was conducted in accordance with the Helsinki Declaration and the standards of the Ethics Committee. Written informed consent was obtained from all patients in this study.

    Consent for publication

    Not applicable.

    Copyright

    © The Author(s) 2018.

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