1Hospital Brasilia and University Hospital of Brasilia, University of Brasilia, Brasília 70390-108, Federal District, Brazil.
2Hospital Brasilia, University of Brasília, Brasília 70390-108, Federal District, Brazil.
3Hospital Brasilia, Brasília 70390-108, Federal District, Brazil.
4Ministry of Health, Brasília 70390-108, Federal District, Brazil.
Correspondence Address: Dr. Sergio Renato Pais-Costa, Hospital Brasilia and University Hospital of Brasilia, University of Brasilia, SEPS 710/910, Sala 330, CEP: 70390-108 - Brasília - DF - Brazil. E-mail:
© The Author(s) 2018. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Aim: Even though laparoscopic hepatectomy (LH) has proved to be both safe and effective in specialized centers; the restricted indications for resection in the case of benign liver lesions has resulted in poorly reported outcomes. Our aim was to describe the short and long-term results of LH to treat benign hepatic lesions, including quality of life (QoL) evaluation.
Methods: Thirty-one LHs were performed between 2007 and 2018 in 30 patients. We evaluated QoL with the SF-36 test and a body image satisfaction questionnaire by personal interview before surgical treatment and at 1 month, 3 months, 6 months and 1 year after surgery.
Results: Median age was 38 years (range 21-71) and the majority were females (68%). The most frequent etiology was hepatic adenoma in 16 patients (52%), followed by focal nodular hyperplasia (n = 4), cavernous hemangioma (n = 3), hepatic abscess (n = 3), cystadenoma (n = 5) and hepatolithiasis (n = 1). The majority of resections were minor (66%) and the conversion rate was 6.2%. Pathological examination confirmed negative margins in all patients. Postoperative mortality was nil, while morbidity was 6.2%. Median hospital stay was 4 days (range 1-32 days). In a median follow-up of 48 months (range 2-120), 2 patients experienced recurrence. QoL variables were similar between the preoperative and postoperative periods.
Conclusion: LH should be considered the main therapeutic approach for treating selected patients with benign liver lesions who require surgical resection because it presented both null mortality and low morbidity, along with rare recurrence, a good quality of life and high esthetic satisfaction.
Laparoscopic liver surgery, liver neoplasms, adenoma, liver cell, focal nodular hyperplasia, hemangioma, cavernous, quality of life
Since the early 90s, when the first laparoscopic anatomical resection of the liver was reported, laparoscopic hepatectomy (LH) has gained increasing importance for treating hepatic tumors. Several advances in laparoscopic instruments such as parenchymal transection devices, staplers and hand-assisted equipment, together with improved expertise in laparoscopic surgery, have led to increasing use of LH, especially in referral centers. Given its many advantages over open hepatectomy, including less postoperative pain, less use of opiate analgesia, better cosmetic results, decreased blood loss, decreased postoperative complications (both hepatic-specific and pulmonary) and shorter hospital stay, LH has become the preferred approach for treating benign hepatic tumors[2-7]. Even though LH has been shown to be both safe and effective; the restricted indications for resection in the case of benign liver lesions have resulted in poorly reported long-term outcomes. In addition, there is a need to know whether LH might improve the overall postoperative quality of life (QoL) of patients with benign lesions[8-15].
The aim of the present study was to evaluate the short and long-term outcomes of LH for benign liver tumors, with special emphasis on postoperative QoL results.
Between June 2007 and March 2018, 81 LHs were performed by a single surgical team in two hospitals (Hospital Santa Lucia between 2007 and 2014 followed by Hospital Brasilia between 2014 and 2018). Of these, 31 (38%) LHs performed in 30 patients bearing benign hepatic lesions formed the study population.
The indications for resection of benign liver lesions were as follows: symptomatic patients, presence of cystadenoma, presence of hepatolithiasis and uncertain diagnosis based either on imaging or on biopsy findings (when it was not possible to rule out malignant hepatic neoplasm). Hepatic adenoma (HA) was also resected in the following circumstances: larger than 4-5 cm, female gender with intention to conceive, presence of beta-catenin mutation or male gender. Resection of pyogenic liver abscess (PLA) was indicated after failure of percutaneous drainage. All patients were studied with serum tumor markers (CEA, AFP and Ca 19.9), abdominal ultrasonography, computed tomography and magnetic resonance imaging (MRI). For the last seven cases, MRI with hepatobiliary contrast (Primovist; Bayer-Schering, Berlin, Germany) was also carried out. Since 2007, our team has considered the laparoscopic approach as the first choice for all hepatectomies except in the following situations: very large lesions (> 10 cm) in the right lobe, tumors close to major vascular structures, or central locations. All liver resections were defined in accordance with the International Hepato-Pancreato-Biliary Association terminology through the Brisbane Nomenclature, 2000. Major hepatectomy was defined as resection of three or more hepatic segments. The surgical techniques used for LH were either the intra-hepatic Glissonian approach [Figures 1 and 2] or the extra-hepatic Glissonian approach [Figures 3 and 4], in accordance with previous standardization[7,11-13]. Intraoperative ultrasonography was performed whenever available. Surgical specimens were preferentially removed in an Endobag [Figure 5], by means of a Pfannenstiel incision [Figure 6] or a small right subcostal incision. On the liver bed, a hemostatic Surgicel was used, along with fibrin glue (Eviscel) when available, to finish the hemostasis. Finally, drains were placed only for major hepatectomies. Postoperative morbidity was defined in accordance with the Clavien-Dindo classification of surgical complications. Biliary fistula was defined using the International Study Group of Liver Surgery classification. Follow-up included physical examinations and hepatic blood tests every three months, as well as abdominal imaging (CT or MRI) twice a year. Recurrence was considered when a lesion reappeared on imaging examinations and was finally confirmed by means of histological analysis. QoL was measured by means of a QoL questionnaire using the Short-Form Health Survey (SF 36), as previously reported by Giuliani et al.. This test was administered by means of a personal interview before surgery and at 1, 3, 6 and 12 months after surgery. In addition, a simple non-validated questionnaire was also performed including the following questions: (1) satisfaction of surgical scar; (2) exposure of body image when wearing bikinis, shorts, “summer clothes”, etc.; (3) change of daily behavior (social, type of the clothes, sportive practices); and (4) recommendation of the LH to other patients. The responses were classified into positive or negative. All these questions were considered to evaluate body image satisfaction regarding the esthetics aspects after LH.
Figure 1. Intrahepatic Glissonian approach for right posterior sectionectomy. Demarcation of liver surface around right posterior Glissonian pedicle
Figure 2. Intrahepatic Glissonian approach for right hepatectomy. En-bloc stapling of right glissonian pedicles by means of vascular stapler (after two hepatotomy procedures)
Categorical variables are described using percentages. Continuous variables are expressed as means and standard deviation for symmetrically distributed, and median (range) for nonsymmetrically distributed data. Differences in SF-36 QoL questionnaire scores between preoperative evaluations and postoperative evaluations were analyzed using two-way repeated measures ANOVA and each patient was in his or her own control at the time of the evaluation. There were no significant outliers in pairwise comparisons and normality assumption held at Shapiro-Wilk test using residuals. We used Wilks’ lambda as an omnibus test statistics for differences between the means of QoL evaluations. Within-subjects effects were evaluated by F-test with Greenhouse-Geisser correction due to unequal variances of the differences between all combinations of related groups, as assessed by Mauchly’s test. Post hoc pairwise comparisons were calculated with Bonferroni adjustment for multiple comparisons. We reported exact P values up to 0.001 and the significance level was set to 0.05 (5%) for statistical inference. Statistical analyses were performed using PASW Statistics 18 (SPSS Inc., Hong Kong, 2015).
The general characteristics of the study population are detailed in Table 1. Median age was 38 years (range 21-71) and the majority were females (70%). The most frequent etiology was HA in 16 patients (50%). Among symptomatic patients (n = 3) who underwent LH, two of them had giant hepatic hemangiomas while the third patient had a giant focal nodular hyperplasia (FNH). Their symptoms were as follows: abdominal pain and sensation of epigastric fullness (n = 2) and visceral compression (n = 1). For most patients, preoperative diagnosis was made from typical findings seen on either CT or MRI. Three patients with HA underwent a percutaneous biopsy that confirmed the presence of beta-catenin mutation. One patient underwent intraoperative frozen-section biopsy because preoperative examinations presented a differential diagnosis with hepatocellular carcinoma, and FNH was then confirmed in this case. There were 3 patients who presented multiple lesions, 1 patient had 6 lesions (FNH) and 2 patients had 3 lesions each (HA).
|Gender, female, n (%)||21 (70)|
|Age, years, median (range)||38 (21-71)|
|ASA risk score, n (%)|
|Previous open abdominal surgery, n (%)||6 (20)|
|Etiology, n (%)|
|Focal nodular hyperplasia||4 (13)|
|Pyogenic liver abscess||3 (10)|
|Non-oriental hepatolithiasis||1 (3)|
|Number of lesions, median (range)||1 (1-6)|
|Lesions size, cm, median (range)||5 (3-13)|
Thirty-one liver resections were performed in 30 patients (1 patient underwent 2 independent resections, both of them by means of a laparoscopic approach). The majority of liver resections were minor (64.5%) and there were two open conversions in this series (6.4%). One patient underwent conversion due to severe intraoperative bleeding (> 750 mL) and the other due to technical difficulties. The first was an obese male operated on for a 10 cm symptomatic giant hemangioma in the dome of the left liver, very close to the left hepatic vein, which was injured due to a stapler failure. The stapler was fired but it was not possible to open it and, thus, an open repair became necessary. This patient was the only one in this series who required postoperative blood transfusions (3.3%). The second case was a female with a cystadenoma in the left lobe who presented multiple adhesions between the small intestine and the liver due to a previous surgery. Pringle maneuver was performed in a single case who underwent open conversion due to intraoperative bleeding. Eight patients underwent surgical drainage of the liver bed by means of a tubular drain. Details of the surgical procedures are shown in Table 2.
Operative characteristics and postoperative outcomes
|Type of hepatectomy, n (%)|
|Right hepatectomy||4 (12.9)|
|Left hepatectomy||6 (19.3)|
|Segmentectomy 5||2 (6.4)|
|Segmentectomy 6||1 (3.2)|
|Segmentectomy 3||1 (3.2)|
|Segmentectomy 2||1 (3.2)|
|Operative time, min, median (range)||135 (60-265)|
|Blood loss, mL, median (range)||125 (0-1000)|
|Major morbidity, n (%)||2 (6.2)|
|Mortality, n (%)||0 (0)|
|Hospital stay, days, median (range)||4 (1-32)|
|Time to normal activities, days, median (range)||14 (7-32)|
Two patients (6.4 %) presented postoperative complications (grade 3), and these were the same 2 patients who underwent open conversion [Table 2]. One patient presented a biliary fistula that required endoscopic retrograde cholangiopancreatography with stent placement, and the other developed an incisional hernia that required a laparoscopic repair six months after surgery. There was no gas embolism in this series. Mortality was nil. The median hospital stay was 4 days (range 1-32 days) for the overall series, and 2 days (range 1-3 days) considering only the minor resections. Eighteen patients required low doses of common analgesics for 2 or 3 days during their postoperative course, while 10 patients required them for 4 days and 2 patients for 6 days. Both patients who underwent open conversion required narcotic analgesia. The median length of time taken to return to normal daily activities was 14 days (range 7-32 days) for the overall series, and 9 days (range 7-12 days) considering only the cases of monosegmentectomy. These findings are shown in Table 2. Among the symptomatic patients, all of them achieved complete symptom relief. Histological examination confirmed negative surgical margins in all patients. Preoperative diagnosis was confirmed in all but 2 patients (93%), who underwent oncological LH because of typical features of hepatocellular carcinoma on preoperative imaging (wash-in/wash-out), but definitive pathological evaluation showed HA in both cases. The median length of follow-up in this series was 48 months (range 2-120 months). Two patients experienced disease recurrence during follow-up. The first recurrence occurred in a young woman two years after right posterior sectionectomy due to HA. She developed a new HA in the left lobe and finally underwent a successful laparoscopic resection of segment III. The second recurrence occurred ten years after left hepatectomy for PLA in a 78-year-old man. He presented a new very large solid-cystic abscess in the right hepatic lobe (segments 7 and 8), for which he underwent open unroofing and finally died due to postoperative infectious complications and sepsis.
We observed a statistically significant decrease of the overall QoL in seven measured variables (except social) at early postoperative period until one month [Table 3]. However, after one month of the postoperative period we observed a statistically significant increase of the all Qol variables. Thus all Qol variables were similar between the preoperative and postoperative periods after 3 months from surgical intervention. These variables were maintained similar until 12 months. Both role emotional and mental health variables presented a great improvement after postoperative period [Table 3]. Application of the questionnaire to evaluate esthetic body image after surgery showed that 93% of the patients considered that their result was satisfactory. Only the two patients who underwent open conversion were dissatisfied with their esthetic result.
|Dimension||Time||Mean (SD)||Multivariate modela||Within subjectsb||Baseline contrastc||Last period contrastc|
|Physical functionating||Baseline||96.9 (2.5)||< 0.001||< 0.001|
|1 mo||93.1 (5.5)||0.002||0.002|
|3 mo||94.7 (5.2)||0.22||0.001|
|6 mo||95.5 (4.9)||0.98||0.004|
|12 mo||96.4 (3.9)||1.00||0.39|
|Social functionating||Baseline||99.4 (0.7)||0.48|
|1 mo||98.8 (2.9)|
|3 mo||99.3 (1.3)|
|6 mo||99.6 (0.7)|
|12 mo||99.7 (0.6)|
|Mental health||Baseline||91.7 (5.1)||< 0.001||< 0.001|
|1 mo||93.2 (8.1)||1.00||1.00|
|3 mo||95.8 (4.2)||0.002||0.29|
|6 mo||97.9 (2.5)||< 0.001||0.023|
|12 mo||97.2 (3)||< 0.001||1.00|
|Bodily pain||Baseline||97.4 (2.2)||< 0.001||0.032|
|1 mo||95.4 (6.2)||0.81||0.81|
|3 mo||96.5 (4.5)||1.00||0.40|
|6 mo||97.6 (2.8)||1.00||0.09|
|12 mo||97.6 (2.8)||1.00||1.00|
|1 mo||96.4 (4.8)||0.29||0.29|
|3 mo||95.7 (5)||0.044||1.00|
|6 mo||97.2 (3.4)||1.00||0.007|
|12 mo||98.5 (2.1)||1.00||0.035|
|Role physical||Baseline||93.1 (2.9)||0.008||< 0.001|
|1 mo||90.3 (5.6)||0.01||0.01|
|3 mo||92.4 (3.8)||1.00||0.003|
|6 mo||92.8 (3.4)||1.00||1.00|
|12 mo||93.8 (2.9)||1.00||0.13|
|Role emotional||Baseline||89.5 (7.1)||< 0.001||< 0.001|
|1 mo||93.2 (5.2)||0.45||0.45|
|3 mo||95.9 (3.6)||0.005||0.69|
|6 mo||96.4 (3.1)||0.001||0.99|
|12 mo||97.3 (2.7)||< 0.001||0.08|
|General health||Baseline||95.6 (7.6)||< 0.001||0.037|
|1 mo||97.5 (1.2)||1.00||1.00|
|3 mo||98.7 (1.2)||0.26||< 0.001|
|6 mo||99.1 (0.8)||0.11||0.61|
|12 mo||99.4 (0.9)||0.24||0.83|
Since initial experiences, LH has been proven to be a good choice for treating benign hepatic lesions, especially for minor resections of lesions arising in easily accessible hepatic segments at anterolateral positions, so-called “laparoscopic hepatic segments”[2-6]. Since 2008, two major international expert consensus conferences have been held to review the role of LH. The first of these was held in Louisville, USA, where it was established that LH was best indicated for solitary lesions measuring 5 cm or less that were located in segments 2 to 6. At this meeting, it was accepted that laparoscopy should be considered the standard approach for left lateral sectionectomy and that indications for surgical treatment of benign hepatic lesions should not be widened simply because laparoscopic approach was feasible. Six years later, a new consensus meeting involving many worldwide experts was held in Morioka, Japan, where hepatic resections of greater complexity became more accepted, including major resections or resections of posterosuperior liver segments, especially at referral centers. Therefore, LH is nowadays considered a safe and feasible alternative to open operations, even for left or right major hepatectomies and malignant liver lesions.
Given that LH is a complex laparoscopic procedure, laparoscopic left lateral sectionectomy has been considered by many experts the ideal anatomical resection for initial training because of its anatomical accessibility and the possibility of using the aid of staplers[18-22]. Therefore, laparoscopic left lateral sectionectomy has been one of the most performed types of LH along the learning curve of many authors[8,10,12]. Even though laparoscopic left lateral sectionectomy and right posterior sectionectomy were the most frequent LHs performed in the present series, more complex LHs including left hepatectomy, right hepatectomy and even mesohepatectomy were also performed, reflecting the strong trend in the literature towards performing more complex procedures for treating hepatic lesions[2-13,15,23].
Many studies, including meta-analyses, have confirmed the benefits of LH in comparison with open hepatectomy, namely: lower levels of postoperative pain, fewer peritoneal adhesions, shorter hospital stay, earlier return to daily activities, lower blood loss, reduced morbidity, fewer operative complications and less mortality[2-15,18-29]. Among the short-term outcomes from our study, a low blood loss (mean 125 mL), short hospital stay, low morbidity (6.4%) and no mortality are clearly in accordance with the many advantages reported in previous studies. The surgical margin was adequate in all cases, despite the lack of intraoperative palpation that is inherent to this method. Late recurrence in this series was a rare event (only 6%), and given that they occurred distant in liver parenchyma, they could perhaps be attributed to more aggressive biological behavior in those two cases.
Benign lesions of the liver usually occur in young patients, who care not only to achieve an early return to work and sports practice, but also to maintain a good QoL and a pleasing body image. Giuliani et al. have demonstrated that the laparoscopic approach was superior regarding the QoL of patients who underwent operations due to benign liver lesions. In the present study we observed that there was an excellent QoL among the patients who underwent successful LH without open conversion. Seven out of eight variables measured by the SF 36 questionnaire presented similar results between preoperative period and postoperative period (after three months of surgical procedure). In our view point, this finding may indicate that LH allows QoL maintenance in patients operated from benign diseases. In the present study, an early return to work and sports practice was observed and, since most of the patients were young and in a productive phase of their lives, a significant socioeconomic gain could be expected from this population group. The main limitations of this study are its retrospective nature, as well as the heterogeneous and relatively small patient population. However, to our knowledge, no case series in Brazil have evaluated early and late postoperative outcomes along with the QoL of patients after LH performed solely on benign lesions of the liver. In addition, this report is unique because most of the patients in this sample were young women who live in a tropical country where body image is a very important tool for evaluating the overall QoL. Thus, a simple satisfaction questionnaire was applied in addition to the QoL questionnaire and showed that about 93% of our patients were satisfied in relation to the general esthetic aspects of the laparoscopic approach.
In conclusion, LH presented low morbidity, null mortality and rare recurrence in the present series. Furthermore, LH offered a good QoL and high esthetic satisfaction. Therefore, LH performed by expert liver surgeons should be considered the main therapeutic approach for treating selected patients with benign liver lesions who require surgical resection. Further prospective studies are needed to confirm our findings.
Contribution to conception and design, and analysis and interpretation of data, giving the final approval of the version to be submitted and any revised version: Pais-Costa SR
Contribution to selection of the studies and literature which were included in the references and drafting the article and revising it critically for important intellectual content: Lima OAT
Contribution with acquisition and collection of data: Costa GC
Contribution to statistical analyses : Martins SJAvailability of data and materials
Data of the patients were collected from their archives in Dr. Pais-Costa’s personal clinic, Oncodigestiva - Digestive Surgery Institute. The patients only authorized this study.Financial support and sponsorship
None.Conflicts of interest
All authors declared that there were no conflicts of interest.Ethical approval and consent to participate
This study was approved by hospital ethics committee of Hospital Brasília. Consent to participate was obtained.Consent for publication
© The Author(s) 2018.
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