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Mini-invasive Surg 2019;3:24.10.20517/2574-1225.2019.20© The Author(s) 2019.
Open AccessPerspective

Minimally invasive surgery for non-achalasia primary esophageal motility disorders is currently underused

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1Department of Surgery, Federal University of Sao Paulo, Sao Paulo, SP 04037-003, Brazil.

2Department of Surgery, Hospital Alemán of Buenos Aires, Buenos Aires C1118 AAT, Argentina.

Correspondence Address: Dr. Fernando A. M. Herbella, Department of Surgery, Escola Paulista de Medicina, Federal University of Sao Paulo, Rua Diogo de Faria 1087 cj 301, Sao Paulo, SP 04037-003, Brazil. E-mail: herbella.dcir@epm.br

    Science Editor: Giulio Belli | Copy Editor: Cai-Hong Wang | Production Editor: Tian Zhang
    ...

    © The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

    Abstract

    Surgical treatment for non-achalasia primary esophageal motility disorders is reserved for few situations. Proper selection of patients brings good outcomes with low morbidity, which makes surgical therapy an adequate therapeutic option. High resolution manometry reclassifies esophageal motility disorders. Interestingly, literature is scarce on surgical therapy for this new classification with per oral endoscopic myotomy as the leading treatment.

    High resolution manometry reclassifies esophageal motility disorders based on the Chicago 3.0 classification[1]. Even though there is a certain correspondence between previous and current classifications[2], a distinct nomenclature arrived based on newly developed - and putatively more objective and accurate - parameters. Thus, primary esophageal motility disorders (PEMD) are probably better diagnosed and evaluated.

    Achalasia is surely the most understood PEMD. Other PEMD are not as well comprehended nor have defined therapy options. These other diseases defined by specific manometric pictures may occur as PEMD or secondary to gastroesophageal reflux disease (GERD)[3]. If GERD is present, the motility abnormality is considered secondary, and treatment is directed toward reflux. In the absence of GERD, therapy is aimed at the modulation of the esophageal dysmotility with pharmacological agents or at the permeabilization of the gastroesophageal junction with endoscopic or surgical procedures[4].

    Surgical treatment for non-achalasia PEMD was reserved for few situations during the conventional manometry era. Cardiomyotomy (Heller’s operation) and fundoplication are used for patients with hypertensive lower esophageal sphincter, diffuse esophageal spasm or nutcracker esophagus and obstructive symptoms[5,6]. Proper selection of patients is linked to good outcomes with low morbidity, which makes surgical therapy an adequate therapeutic option. Interestingly, literature is scarce on surgical therapy for this new classification with per oral endoscopic myotomy (POEM) as the leading treatment.

    Ineffective esophageal motility is not treated by surgery. Hypertensive lower esophageal sphincter is no longer a PEMD according to Chicago 3.0.

    There are no studies on Heller’s myotomy for distal esophageal spasm (previously diffuse spasm) based on the new classification. Some case reports of POEM for distal spasm have been reported[7-9] with multicenter studies encompassing a larger number of patients but always inferior to 20 in total[10]. Experience with the method is too short to draw conclusions. The same is true for jackhammer esophagus: no studies on Heller’s myotomy and few case reports for POEM[9,11]. A recent systematic review compiling these small series[12] showed a clinical success of 90%.

    Esophagogastric junction outflow obstruction is an altered motility pattern contemplated by Chicago 3.0 classification. Most cases are associated to mechanical obstruction especially after operations in the area. Few cases are considered PEMD[13]. Interestingly, some cases treated by Heller’s myotomy[13-15] showed good outcomes while POEM did not show good results[16].

    In conclusion, Heller’s myotomy and fundoplication are currently underused for the treatment of non-achalasia PEMD. POEM is the preferred treatment, but long-term results with larger series are still elusive.

    Declarations

    Authors’ contributions

    Made substantial contributions to conception and design of the study and performed data analysis and interpretation: Herbella FAM, Schlottmann F

    Availability of data and materials

    Not applicable.

    Financial support and sponsorship

    None.

    Conflicts of interest

    All authors declared that there are no conflicts of interest.

    Ethical approval and consent to participate

    Not applicable.

    Consent for publication

    Not applicable.

    Copyright

    © The Author(s) 2019.

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