1Department of Obstetrics and Gynecology,
2Department of Obstetrics and Gynecology,
3Graduate Institute of Clinical Medicine,
Correspondence Address: Dr. Feng-Hsiang Tang, Department of Obstetrics and Gynecology, Kaohsiung Municipal Ta-Tung Hospital, No. 68, Zhonghua 3rd Rd., Qianjin Dist., Kaohsiung 801735, Taiwan. E-mail: firstname.lastname@example.org
© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Aim: We aimed to evaluate the feasibility of single-port laparoscopic myomectomy in the virgin womb.
Methods: A retrospective chart review of 31 consecutive cases between November 2017 and October 2019 performed by a single surgeon was performed.
Results: The mean age of patient was 50.10 ± 7.79 years old. The mean BMI was 23.55 ± 4.36 kg/m2. The mean number of myoma in single patient was 3.84 ± 2.45 pieces. The mean maximum diameter of myoma in single patient was 11.24 ± 3.27 cm. The mean operation time was 182.32 ± 52.39 min. The mean blood loss was 231.77 ± 238.90 mL. The Visual Analogue Score (VAS) of pain when immediately arriving at the ward after operation was 2.32 ± 1.60. The VAS after 24 h dropped to 1.23 ± 1.43. In total, 119 myomas were removed in our study. There were 15 (48.4%) women with more than four myomas. Fifteen (48.4%) women had more than two myomas that were > 5 cm. There were 58 (48.74%) intramural myomas, with mean diameter of 6.72 ± 4.41 cm. Fifty-two (43.70%) subserous type myoma were removed with mean diameter 2.58 ± 3.35 cm. Posterior myoma accounted for five (4.20%) pieces with mean diameter of 9.30 ± 4.49 cm. The broad ligament type myoma accounted for four pieces (3.36%), and the mean diameter was 3.74 ± 1.87 cm. There were 51 (42.9%) myomas > 5 cm in diameter. Among the different types of myoma, there were 36 (62.1%) intramural type and 6 (11.5%) subserous type, and all posterior and broad ligament type were > 5 cm in diameter. The blood loss and operation time showed no relationship to myoma number. There were differences in blood loss (P = 0.0359) and operation time (P = 0.0537) based on the maximum diameter of myoma. No learning curve was noted in the cumulative sum control chart analysis of the 31 consecutive cases.
Conclusion: In our 31 consecutive cases, the operation time, blood loss, and postoperative VAS score were all comparable to the previously published literature for single-port laparoscopic myomectomy. It is feasible for virgin women with symptomatic myoma to receive single-port laparoscopic myomectomy.
Single-port laparoscopy, myoma uteri, virgin
Myoma uteri, a monoclonal smooth muscle cell tumor, is the most common benign gynecologic tumor in women in childbearing age. Its prevalence varies from 4.5% to 68.6% in different studies and tends to increase with age. The self-reported prevalence of myoma uteri is 1.8% in 20-29-year-old women, but it increases to 7.0% and 14.1% in the 30-39- and 40-49-year-old groups, respectively.
The symptoms of myoma uteri are annoying and negatively impact the quality of life. Over one third of patients report heavy menstrual bleeding, prolonged duration of menstrual bleeding, and bleeding between periods. Moreover, over 50% of women with myoma uteri report having pain and abdominal cramps during periods, nearly one third report pressure on bladder or inside the abdomen, and nearly 25% feel pain during sexual intercourse. When asked about their symptoms in the last 12 months, over half (50.6%) of women with myoma uteri reported a negative impact on their daily life. Moreover, women with myoma uteri have significantly higher frequency of genitourinary symptoms including stress urinary incontinence, mixed urinary incontinence, urgency, daytime frequency, and dyspareunia.
Women with myoma uteri can only receive observation when there are no symptoms. Symptomatic myoma needs either medical or surgical treatment. Medical treatment of myoma uteri includes levonorgestrel intrauterine system, tranexamic acid, non-steroid anti-inflammatory drugs, contraceptive pills, and oral or injected progestogens. These treatments can decrease menstrual blood flow or relieve pain, but are not effective in decreasing the size of the myoma. Gonadotropin releasing hormone analogs can effectively decrease myoma size and uterine volume. However, the side effects preclude its long-term use. Ulipristal acetate is a selective progesterone receptor modulator that exhibits direct tissue-specific partial progesterone antagonist effects. It is an effective option for both preoperative and intermittent treatment of moderate to severe, symptomatic uterine fibroids in women of reproductive age. However, the long-term effect is still not known, and in rare case it can cause severe liver damage.
Surgery is a definite treatment for symptomatic myomas, especially for large ones. The bulky effect usually cannot regress quickly enough using non-surgical methods. Hysterectomy is performed if the patient does not want to preserve her uterus. Myomectomy is an alternative method if the patient chooses to preserve her uterus or the woman has not yet completed her childbearing. With the progression of minimally invasive surgery, many surgeons who are familiar with laparoscopic surgery will choose to perform laparoscopic myomectomy in those patients. Single-port laparoscopic myomectomy is more technically difficult but has comparable surgical outcomes to conventional laparoscopic myomectomy, with the benefit of good cosmetic results. In this study, we retrospectively analyzed the surgical outcomes of 31 women who had had no sexual experience with symptomatic myomas receiving single-port laparoscopic myomectomy without using uterine manipulator to preserve their virginity in our hospital performed by single surgeon.
This was a retrospective chart review of consecutive 31 women without sexual experience who presented with symptomatic uterine myomas and received single-port laparoscopic myomectomy without using uterine manipulator between November 2017 and October 2019. The hospital setting is a regional teaching hospital (Kaohsiung Municipal Ta-Tung Hospital) but all staff are also members of a medical center (Kaohsiung Medical University Hospital) in Kaohsiung, Taiwan. All surgeries were done by the same gynecologist who is experienced in minimally invasive gynecologic surgery. The inclusion criteria were women with myoma uteri and symptoms such as menometrorrhagia, which causes anemia (Hemoglobin < 11 g/dL), or bulky effect, which cause bearing down sensation, frequency, tenesmus, back soreness, or a palpable pelvic/abdominal mass. The exclusion criteria were as follows: (1) malignancy could not be ruled out by image study; (2) patient was found to have severe adhesion or endometriosis requiring combined major operation at the same time; and (3) patient presented with complex medical condition before operation that required combined care by physician specialists. The largest diameter of myoma was recorded by image study (trans-abdominal ultrasound, abdominal CT, or pelvic MRI). The position and number of myoma was recorded during the operation. The operation time and blood loss were recorded by circulating nurse. The postoperative pain was recorded by charting nurse at bedside immediately when the patient arrived at the ward after operation and 24 h later. The pain score was measured by the Visual Analogue Scale. Postoperative fever over 38 °C and prolonged for 48 h was recorded as a complication. Other perioperative complications within 30 days were recorded. Patients were discharged from the hospital after well tolerating oral intake, successful ambulation, and absence of postoperative fever. All patients were scheduled for follow-up examinations at one week and one month after discharge.
The patient is in the supine position. General anesthesia is selected and tracheal intubation is performed to maintain the airway. A single dose of cefazolin (1 g) is given by intravenous bolus method before operation. The dose is doubled if the patient’s body weight is over 80 kg. A Foley catheter is inserted after anesthesia for bladder emptying. We do not use uterine manipulator in these women to preserve their virginity. A 1.5-cm vertical incision is done at umbilicus after sterile preparing and draping of abdomen and within 30 min of intravenous bolus antibiotics. A multi-instrument laparoscopic port (LagiPortTM Kit, Lagis, Taichung, Taiwan) is inserted through the umbilical incision and properly positioned. We insert a 10-mm telescope to view the pelvic cavity. The circulating nurse records the number and position of myomas. Before uterine incision is performed, diluted vasopressin (1:200 with normal saline) is injected around myomas until bleaching change is seen. We use cold knife scissors to cut the uterine surface until the body of the myoma is reached. An electrothermal bipolar tissue sealing system (LigaSureTM, Medtronic Parkway, MN, USA) is used to control bleeding if necessary. After enough of the myoma body is revealed, a laparoscopic myoma screw is screwed into the myoma body for traction and direction. Then, further dissection of the myoma can be done step by step. After the myoma is removed from the uterine body, we use barbed suture to close the uterine wall defect for at least two layers in intramural type myoma. For superficial subserous myoma or broad ligament myoma, one-layered barbed suture is used if sufficient. After all uterine incisions are sutured, we apply fibrin sealant (Tisseel, Baxter AG, Vienna, Austria) on the suture surface to improve healing and decrease oozing. Large myomas are removed from the umbilical incision by cold knife morcellation. A multi-instrument laparoscopic port is placed again to check for bleeding under telescope. Then, 800 mL of 4% Icodextrin solution (Adept, Baxter AG, Vienna, Austria) are infused into the pelvic cavity after clearing blood clot to prevent adhesion. The umbilical incision is sutured layer by layer. All the apparatuses used in our surgery are conventional laparoscopic instruments; no articulated instruments were used in our study.
All data were calculated using JMP Pro 15 (SAS Institute Inc.) and Excel (Microsoft Inc.). The relationships of myoma number and size to operation time and blood loss were calculated by one-way ANOVA, with P value < 0.05 as significant. The control chart of learning curve was calculated by the cumulative sum control chart (CUSUM) method.
The demographic data of all 31 women are listed in Table 1. The mean age of the patient was 50.10 ± 7.79 years (95%CI: 47.24-52.95 years). The mean BMI was 23.55 ± 4.36 kg/m2 (95%CI: 21.95-25.15 kg/m2). The mean number of myoma in single patient was 3.84 ± 2.45 (95%CI: 2.94-4.74). The mean maximum diameter of myoma in single patient was 11.24 ± 3.27 cm (95%CI: 10.04-12.44 cm). The mean operation time was 182.32 ± 52.39 min (95%CI: 163.11-201.54 min). The mean blood loss was 231.77 ± 238.90 mL (95%CI: 144.14-319.40 mL). The Visual Analogue Score (VAS) of pain when immediately arriving at the ward after operation was 2.32 ± 1.60 (95%CI: 1.74-2.91) and dropped to 1.23 ± 1.43 (95%CI: 0.70-1.75) after 24 h.
The demographic data of patient in chronological series
|Age||BMI (kg/m2)||Number of myoma||Max diameter of myoma (cm)||Operation time (min)||Blood loss (mL)||VAS score 1*||VAS score 2**|
|Mean||50.10 ± 7.79||23.55 ± 4.36||3.84 ± 2.45||11.24 ± 3.27||182.32 ± 52.39||231.77 ± 238.90||2.32 ± 1.60||1.23 ± 1.43|
In Table 2, we describe the position and size of all myomas in all 31 patients in our study. Traditionally, posterior wall intramural myoma is thought to be more difficult to deal with laparoscopically, especially when there is no uterine manipulator use. We divided them by the intramural type myoma and position. In total, 119 myomas were removed in our study. There were 58 (48.74%) intramural myomas, with mean diameter of 6.72 ± 4.41 cm (95%CI: 5.55-7.89 cm). Fifty-two (43.70%) subserous type myoma were removed with mean diameter 2.58 ± 3.35 cm (95%CI: 1.65-3.52 cm). Posterior myoma accounted for five (4.20%) pieces with mean diameter of 9.30 ± 4.49 cm (95%CI: 3.72-14.88 cm). The broad ligament type myoma accounted for four pieces (3.36%) and the mean diameter was 3.74 ± 1.87 cm (95%CI: 3.05-14.95 cm).
The position, number and size of myoma uteri of 31 patient (Original data)
|Patient (myoma number)||Intramural||Subserous||Posterior intramural||Broad ligament|
|1(4)||3 (6, 2, 1)*||1(15)|
|2(6)||3 (12, 10, 8)||3 (1, 1, 1)|
|5(3)||1(14)||2 (2, 1)|
|6(3)||1(9)||2 (3, 2)|
|7(8)||2 (14, 6)||6 (3, 2, 1, 1, 0.5, 0.3)|
|8(3)||1(6)||2 (10, 1)|
|9(4)||2 (12, 8)||2 (3, 1)|
|11(7)||3 (10, 6, 4)||4 (3, 2, 1, 0.5)|
|14(7)||3 (8, 6, 5)||4 (10, 8, 1, 0.5)|
|16(4)||1(3)||2 (1, 1)||1(8)|
|17(5)||3 (8, 7, 4)||2 (2, 0.5)|
|18(3)||2 (8, 6)||1(1)|
|19(10)||10 (10, 4, 3, 2, 1.5, 1, 1, 1, 0.5, 0.3)|
|21(4)||4 (20, 5, 4, 3)|
|22(6)||5 (8, 4, 3, 2, 1)||1 (0.5)|
|24(6)||2 (10, 4)||4 (1, 1, 1, 1)|
|27(2)||2 (13, 5)|
|28(7)||2 (8, 7)||4 (4, 2, 1, 0.5)||1(5)|
|29(6)||1 (6.5)||4 (3, 2, 0.5, 0.5)||1 (5.5)|
|30(3)||2 (5, 3)||1(9)|
|31(5)||2 (10, 5)||3 (3, 2, 1)|
|Total (average)||58 (6.72 ± 4.41 cm)||52 (2.58 ± 3.35 cm)||5 (9.30 ± 4.49 cm)||4 (3.74 ± 1.87 cm)|
As shown in Table 3, the number of myomas > 5 cm in diameter was 51 (42.9%). There were 36 intramural myomas > 5 cm of 58 (62.1%), with mean diameter of 9.26 ± 3.46 cm (95%CI: 8.09-10.44 cm). The number of subserous type myomas > 5 cm in diameter was six of 52 (11.5%), with an average size of 10.67 ± 4.18 cm (95%CI: 6.28-15.05 cm). There were no changes in the posterior intramural type and broad ligament type myomas.
The position, number and size of myoma uteri of 31 patient (Data of myoma size ≥ 5 cm)
|Patient (myoma number)||Intramural||Subserous||Posterior intramural||Broad ligament|
|2(3)||3 (12, 10, 8)|
|7(2)||2 (14, 6)|
|9(2)||2 (12, 8)|
|11(2)||2 (10, 6)|
|14(5)||3 (8, 6, 5)||2 (10, 8)|
|17(2)||2 (8, 7)|
|18(2)||2 (8, 6)|
|21(2)||2 (20, 5)|
|27(2)||2 (13, 5)|
|28(3)||2 (8, 7)||1(5)|
|29(2)||1 (6.5)||1 (5.5)|
|31(2)||2 (10, 5)|
|Total (average)||36 (9.26 ± 3.46 cm)||6 (10.67 ± 4.18 cm)||5 (9.30 ± 4.49 cm)||4 (3.74 ± 1.87 cm)|
Figure 1. Distribution of relationship of patient and myoma. A: patient number and the myoma number; B: patient number with myoma ≥ 5 cm; C: distribution of myoma; D: distribution of myomas ≥ 5 cm
There were 20 (64.52%) women with more than three myomas in our study [Figure 1A]. When we deducted all the myoma < 5 cm, there were still 15 (48.39%) women with more than two myomas that were > 5 cm [Figure 1B]. The distribution of different types of myoma is shown in Figure 1C. Intramural myomas accounted for 48%, subserous myoma accounted for 44%, and posterior intramural myoma and broad ligament myoma accounted for 4% each. When only myomas ≥ 5 cm were included, intramural myoma accounted for 70%, subserous myoma dropped to 12%, posterior intramural myoma accounted for 10%, and broad ligament myoma accounted for 8% [Figure 1D].
As shown in Figure 2, we analyzed the relationship between the number of myomas and the blood loss, showing no significant relationship. We also calculated the relationship between the maximum diameter of myoma in a patient with the blood loss, showing a significant relationship.
Figure 2. Relationship of blood loss and the number (A, P = 0.9516) and max diameter (B, P = 0.0359) of myoma
We calculated the relationships between operation time and the number and maximum diameter of myomas. As shown in Figure 3A, there was no significant relationship between operation time and the number of myomas removed. The operation time became longer as the maximum diameter of myoma increased, but this relationship did not reach significance [Figure 3B].
Figure 3. Relationship of operation time with the number (A, P = 0.6378) and max diameter of myoma (B, P = 0.0537)
As to the learning curve, we used the CUSUM method to calculate the learning curve by operation time [Figure 4]. No learning curve was noted in our study.
Concerning to perioperative complications, there were three cases (9.7%) with blood loss over 500 mL, but all could be corrected after intraoperative blood transfusion without any sequalae. There were three cases (9.7%) with postoperative fever > 38 °C and persisted over 48 h. However, all subsided and the patients were discharged after three days of intravenous antibiotics. All 31 patients completed their surgery by single-port laparoscope without changing to multiport laparoscopy or laparotomy. There were no major complications such as bowel, ureter, bladder injuries, or incisional hernia.
During the same period, we also had 10 cases of conventional laparoscopic myomectomy (using three trocars) and 10 cases of non-virgin single-port laparoscopic myomectomy (i.e., using uterine manipulator). We compare them in Table 4. The age was younger in those two groups (50.10 ± 7.79 vs. 42.6 ± 6.02 and 42.8 ± 4.69), and the maximum diameter of myoma was smaller in them (11.24 ± 3.27 cm vs. 7.30 ± 2.06 cm and 8.71 ± 2.05 cm). However, in BMI, number of myomas removed, operation time, blood loss, and VAS score when arriving at the ward and 24 h later, there were no significant differences among the three groups.
Comparison of single port laparoscopic myomectomy (virgin) group, single port laparoscopic myomectomy (nonvirgin) group and conventional laparoscopic myomectomy group
|Single port in virgin||Single port in non-virgin||Conventional 3 port||P value|
|Age||50.10 ± 7.79||42.6 ± 6.02||42.8 ± 4.69||0.0025*|
|BMI (kg/m2)||23.55 ± 4.36||2.199 ± 2.90||24.45 ± 5.21||0.4337|
|Myoma number||3.84 ± 2.45||2.90 ± 1.73||2.60 ± 2.01||0.2413|
|Max diameter of myoma (cm)||11.24 ± 3.27||7.30 ± 2.06||8.71 ± 2.05||0.0008*|
|Operation time (min)||182.32 ± 52.39||152.10 ± 59.38||173.2 ± 76.36||0.3759|
|Blood loss (mL)||231.77 ± 238.90||102.50 ± 146.35||125.00 ± 206.07||0.1757|
|VAS score 1*||2.32 ± 1.60||1.00 ± 1.15||2.80 ± 2.53||0.0586|
|VAS score 2**||1.23 ± 1.43||0.20 ± 0.63||0.80 ± 1.03||0.0818|
We compared our data to previous published literature concerning single-port laparoscopic myomectomy, and the results are shown in Table 5.
|Our studies||Previous published studies|
|Mean number of myoma||3.84 ± 2.45||1-3 to 1-5|
|Mean diameter of max myoma (cm)||11.24 ± 3.27||7-14|
|Operation time (min)||182.32 ± 52.39||77.5 ± 37.8 to 191.4 ± 103.0|
|Blood loss (mL)||231.77 ± 238.90||114.2 ± 157.0 to 224.6 ± 320.9|
|VAS score||2.32 ± 1.06*
1.23 ± 1.43**
|1.60 ± 1.30 to 3.50 ± 0.8|
Since the introduction of laparoscopic myomectomy in 1979 by Semm, numerous studies have been published concerning the feasibility and safety of this minimally invasive method[10-12]. When compared to open laparotomy myomectomy, laparoscopic myomectomy remains a safe and effective surgical option with the advantages of a lower drop in hemoglobin, less postoperative pain, and faster recovery. Concerning the obstetric outcome, both groups show no significant differences in pregnancy rate, abortion rate, and preterm delivery rate.
Recently, technological innovations (such as a multichannel single port, articulating instruments, and high-definition laparoscopes) have allowed laparoscopic surgeons to perform gynecologic surgery through only one small incision over the abdomen (single-port laparoscopic surgery) with the aim of further reducing the invasiveness of conventional laparoscopy. There are many reports applying this new method to gynecologic surgeries such as hysterectomy, adnexal surgery, or even cancer surgery[15-17]. Its use in myomectomy is limited to advanced laparoscopic surgeons due to the difficulty of multiple suturing and tying. However, there are more and more reports on the feasibility and safety of this difficult method[18-22].
In a systematic review and meta-analysis comparing single-port laparoscopic myomectomy with conventional laparoscopic myomectomy published in 2019, Kim et al. concluded that single-port laparoscopic myomectomy is comparable to conventional laparoscopic myomectomy in terms of safety and feasibility and more advantageous in terms of immediate postoperative pain. However, virginity is not mentioned in the literature they included. To the best of our knowledge, this is the first study reporting on the use of single-port laparoscopic myomectomy in virgins.
As is known, it is more difficult in laparoscopic gynecologic surgery to not use a uterine manipulator, especially in myomectomy, which needs the uterine manipulator to change the position of the uterus for proper surgical plane when dissecting myoma and suturing the uterine wall defect.
In our study, the mean number of myoma in a single patient was 3.84 ± 2.45, which is comparable to previous studies[18,19,21-25], which range from 1-5. However, in one patient in our study, 10 myomas were removed in the same operation, which we believe is the most reported in the literature in a single-port laparoscopic myomectomy. The mean diameter of maximum myoma in single patient was 7-14 cm in those studies, and in our study was 11.24 ± 3.27 cm. The maximum diameter of single myoma removed in our study was 20 cm, which we believe is the largest diameter of myoma removed by single-port laparoscopic surgery reported in the literature. The mean operation time in our study was 182.32 ± 52.39 min, which is also comparable to those studies (from 77.5 ± 37.8 min to 191.4 ± 103.0 min). The mean blood loss was 231.77 ± 238.90 mL in our study. The mean blood loss in previous studies ranges from 114.2 ± 157.0 mL to 224.6 ± 320.9 mL. However, there were two extreme values in our study, while the median value of blood loss was 150 mL. We believe the blood loss is comparable to those previous studies. The VAS score in our study was 2.32 ± 1.06 when patients arrived at the ward after operation and 1.23 ± 1.43 24 h later, which is also comparable to those studies (from 1.60 ± 1.30 to 3.50 ± 0.8).
In total, 119 myoma were removed in our study, with 51 (42.86%) being > 5 cm in diameter. All the posterior intramural and broad ligament type myomas were > 5 cm. Overall, 36 of 58 (62.1%) intramural myomas were > 5 cm. Most subserous type myomas were small; only 15 of 52 (28.8%) were > 5 cm. These results are similar to the reference values.
Traditionally, it is thought that intramural type myoma, especially positioned in posterior uterine wall, is more difficult to remove laparoscopically. It needs elevation of the uterus by uterine manipulator to reveal the myoma. Besides, it is difficult in suture the posterior uterine wall defect in a relatively small space (posterior cul-de-sac). In our study, we did not use uterine manipulator to preserve the patient’s virginity. We elevated the uterus by one apparatus and used barbed suture. Then, we could manipulate the uterus by holding the string near the uterine defect [Figure 5]. The benefit of this method is that we could correctly suture on the right plane and angle one at a time.
The relationship of blood loss to the number of myoma removed was insignificant. It might be due to the subserous myoma accounting for a substantial portion of the multiple-myoma patients. However, we did not find any description of the relationship between myoma number and blood loss in the literature. The blood loss was higher when the maximum diameter of myoma was larger. This is reasonable because the greater is the size of the myoma, the narrower is the space in the operation field, which may make it difficult to control bleeding by apparatus when it occurs.
There was no significant relationship between operation time and the myoma number removed. We think it is for the same reason: a substantial portion of multiple myomas was subserous type, which could be removed without difficulty. The operation time was longer when the maximum diameter of myoma became greater, but did not reach significance. We think it is reasonable that removing large myoma is time consuming whether during excision, suturing defect, or removing from the umbilical incision by cold knife blade.
There was no learning curve according to the CUSUM analysis in our study. It may be because the operator is experienced and already familiar with single-port laparoscopic surgery. For those not familiar with single-port laparoscopic surgery, a learning curve may exist to overcome the technical difficulty. However, Torng et al. concluded that a learning curve is not required for laparoendoscopic single site surgery for experienced laparoscopic surgeons.
There is scant literature on the topic of laparoscopic gynecology surgery in virgins. Most of the reports are for diagnostic purposes or case studies on adnexal surgery[29-35]. There is one case report on performing a posterior colpotomy laparoscopically to remove a prolapsed myoma in a virgin’s vagina to preserve her virginity. However, this is done by multiport laparoscope. There is a retrospective study of 297 cases of laparoscopic-assisted vaginal hysterectomy in virgins and nulliparas using Biswas uterine vaginal elevator, but the elevator should be removed laparoscopically after uterus is excised completely. It is not suitable in laparoscopic myomectomy because colpotomy is not necessary. Furthermore, this research is done by multiport laparoscopy.
For virgins with symptomatic myoma, medical treatment can be used. Ulipristal acetate can achieve amenorrhea state sooner than placebo and improves quality of life. In some research, it is used preoperatively, but the benefit is inconclusive. However, there are sporadic cases of liver injuries and hepatic failure reported, and its use should be restricted to those whose liver condition is healthy, and periodic liver monitoring before, during, and after treatment is suggested. The long-term effect of ulipristal acetate on pregnancy still lacks high quality data. Besides, for patient with large myoma, the mass effect does not disappear with its use. Thus, surgery is needed in these patients.
Uterine artery embolization (UAE) is another choice for those group. According to the 10-year outcomes of the randomized EMMY (Embolization vs. Hysterectomy) trial, about two thirds of hysterectomies can be avoided and health-related quality of life remains comparatively stable. However, 35% of patients need secondary hysterectomy after UAE. Furthermore, the pregnancy rate was found to be lower and miscarriage rate higher after UAE than after myomectomy.
High intensity focused ultrasound is a newer method for treating myoma. The response rate ranges 40%-85% in different modalities and studies. However, it is expensive in Taiwan, and the mass shrinks slowly. The long-term effect of high intensity focused ultrasound treatment is still not clearly known for myoma.
Surgery is the only way to remove mass and improve symptoms, especially mass-induced ones. The specimen can be obtained by pathologic examination.
The limitation of this study is that it was a retrospective chart review. Further large-scale randomized research is needed to compare with other methods to clarify its limitations and safety.
In conclusion, this is the first report on single-port laparoscopic myomectomy on the virgin womb. In our 31 consecutive cases, the operation time, blood loss, and postoperative VAS score were all comparable to the previous published literature. Without using uterine manipulator, we could still complete the operation successfully without major complications. The manipulation of the uterus could be achieved by myoma screw or suture string when needed. It is feasible for virgin women with symptomatic myoma to receive single-port laparoscopic myomectomy.
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© The Author(s) 2020.
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